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Cafergot

Cafergot (Ergotamine and caffeine) are used together to treat migraine headache with or without aura. Ergotamine works by constricting blood vessel walls in the head, relieving dilation that causes the pain of migraine headaches. Caffeine helps the ergotamine to be absorbed into the bloodstream more effectively.

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Cafergot is a combination of an ergot alkaloid (ergotamine tartrate) and a stimulant (caffeine). It is used to treat certain types of headaches (vascular headaches including migraine and cluster headaches). Headache pain can sometimes be caused by widened blood vessels in the head. Ergotamine works by narrowing these widened blood vessels. Caffeine increases the absorption of ergotamine and also narrows widened blood vessels.

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